What does this skill do?

The Biological Sciences Expert skill gives an agent professional-level guidance across molecular biology, genomics, bioinformatics, and computational biology.

It covers molecular biology (DNA, RNA, proteins, gene expression, CRISPR), genomics and bioinformatics (sequencing, assembly, alignment, variant and phylogenetic analysis), and systems biology (pathway and network modeling).

It provides concrete analysis capabilities — sequence composition, global and local alignment, variant classification, and RNA-seq normalization and differential expression — and emphasizes reproducible, standards-based workflows.

  • Analyzes DNA/RNA sequences and identifies ORFs and motifs

  • Runs global and local sequence alignment

  • Classifies genomic variants and predicts consequences

  • Normalizes and tests RNA-seq expression data

How it works

1

Frame the analysis

The agent identifies the biology task — sequence analysis, alignment, variant analysis, or RNA-seq — and the relevant data formats.

2

Analyze sequences

It computes composition, transcribes and translates DNA, identifies open reading frames, and detects motifs.

3

Align and classify

It runs Needleman-Wunsch or Smith-Waterman alignment, computes identity, and classifies variants by type and rarity.

4

Interpret expression

It normalizes RNA-seq counts, performs differential expression testing, and identifies marker genes with statistical thresholds.

Best use cases for this skill

  • Sequence analysis: Compute composition, ORFs, and motifs from DNA or RNA.

  • Alignment: Run global or local alignment and compute sequence identity.

  • Variant analysis: Classify SNVs, indels, and predict functional consequences.

  • RNA-seq: Normalize counts and run differential expression testing.

Frequently asked questions

What does the Biological Sciences Expert skill do?

It provides expert-level guidance in biology, biotechnology, genetics, bioinformatics, and computational biology, including sequence analysis, alignment, variant classification, and RNA-seq interpretation.

When should an agent use it?

Use it for molecular biology, genomics, and bioinformatics tasks — analyzing sequences, aligning, interpreting variants, or working with RNA-seq data.

Which formats and tools does it use?

It works with standard formats like FASTA, VCF, and BAM and references tools such as Biopython, NCBI, Ensembl, and Bioconductor.

Does it follow good scientific practice?

Yes. It applies quality control, appropriate statistical tests with multiple-testing correction, independent validation, and reproducible, documented workflows.

Use from source

Ask your Buda agent to install this community skill.

Copy this prompt into your own Buda agent. It includes the source repository and install command so the agent can complete the setup in natural language.

Prompt to send to your Buda agent
Please install the "Biological Sciences Expert Skill" skill into this Buda agent.

Source repository: https://github.com/personamanagmentlayer/pcl
Install command: npx skills add personamanagmentlayer/pcl --skill biological-expert -y -a universal

Please run the install command, verify the skill is available, and tell me any setup notes or follow-up steps from the source repository.
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Install workflow

  1. 1Copy the prompt
  2. 2Send it to your Buda agent
  3. 3Done